diethyl α-formylmalonate
diethyl α-formylmalonate
CAS: 33142-25-5
Molecular Formula: C8H12O5
diethyl α-formylmalonate - Names and Identifiers
| Name | diethyl α-formylmalonate |
| Synonyms | Diethyl -forMylMalonate diethyl2-forMylMalonate diethyl α-formylmalonate Propanedioic acid, 2-formyl-, 1,3-diethyl ester |
| CAS | 33142-25-5 |
diethyl α-formylmalonate - Physico-chemical Properties
| Molecular Formula | C8H12O5 |
| Molar Mass | 188.18 |
diethyl α-formylmalonate - Introduction
diethyl α-formylmalonate(diethyl α-formylmalonate) is an organic compound with the molecular formula C10H16O5.
Nature:
-Appearance: colorless liquid
-Density: 1.129g/cm³
-Melting point:-60 ° C
-Boiling point: 114-115 ° C
-Solubility: Soluble in alcohol, ether and organic solvents such as ethanol and dimethylformamide
-Main functional groups: Ester and aldehyde functional groups
Use:
- diethyl α-formylmalonate can be used as an intermediate for the synthesis of organic compounds, especially for the synthesis of drugs and pesticides.
-It can also be used as a formyl donor in organic synthesis for the synthesis of allyl alcohols and Phenol ethers.
Method:
The preparation method of diethyl α-formylmalonate is usually carried out by the following steps:
1. Reacting diethyl malonate with methanol to produce diethyl 2-methyl malonate.
2. Reacting diethyl 2-methyl malonate with formaldehyde to generate diethyl α-formylmalonate.
Safety Information:
diethyl α-formylmalonate is an organic compound. The following safety precautions must be observed during operation:
-Avoid inhalation, swallowing or contact with skin. Appropriate protective gloves, eye and respiratory protection should be worn.
-When operating, choose a well-ventilated laboratory environment or an exhaust cabinet for organic chemical operations.
-Flame and high temperature can cause diethyl α-formylmalonate to burn, and should be kept away from open flames and heat sources.
-When waste is disposed of, it should be disposed of in accordance with local codes and regulations.
Nature:
-Appearance: colorless liquid
-Density: 1.129g/cm³
-Melting point:-60 ° C
-Boiling point: 114-115 ° C
-Solubility: Soluble in alcohol, ether and organic solvents such as ethanol and dimethylformamide
-Main functional groups: Ester and aldehyde functional groups
Use:
- diethyl α-formylmalonate can be used as an intermediate for the synthesis of organic compounds, especially for the synthesis of drugs and pesticides.
-It can also be used as a formyl donor in organic synthesis for the synthesis of allyl alcohols and Phenol ethers.
Method:
The preparation method of diethyl α-formylmalonate is usually carried out by the following steps:
1. Reacting diethyl malonate with methanol to produce diethyl 2-methyl malonate.
2. Reacting diethyl 2-methyl malonate with formaldehyde to generate diethyl α-formylmalonate.
Safety Information:
diethyl α-formylmalonate is an organic compound. The following safety precautions must be observed during operation:
-Avoid inhalation, swallowing or contact with skin. Appropriate protective gloves, eye and respiratory protection should be worn.
-When operating, choose a well-ventilated laboratory environment or an exhaust cabinet for organic chemical operations.
-Flame and high temperature can cause diethyl α-formylmalonate to burn, and should be kept away from open flames and heat sources.
-When waste is disposed of, it should be disposed of in accordance with local codes and regulations.
Last Update：2024-04-09 02:00:45
